In this webinar we will present a unique development that enables correlative microscopy by using a central software platform to bring together data from light, electron, ion and X-ray microscopy (XRM). Beyond simply correlating the different data sets, the approach allows data from one technique to be used to drive the hardware of another technique, facilitating easy transfer of information between the suite of microscopes implemented.

In a proof-of-concept approach, we have started to develop brain preparation, scanning and cross-correlation pipelines to exploit the virtues of complementary high-resolution neuroimaging techniques (MRI, 3D polarised light imaging, X-ray tomography, 3D SEM, Multibeam SEM (mSEM) and FIB SEM) applied serially to the same brain tissue. The main aim is to develop a multiscale approach that will allow, for example, the study of the human connectome from the millimetre to the nanometre scale.